The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system. It is home to three schools: the School of Medicine, the Graduate School of Biomedical Sciences, and the Graduate School of Nursing, as well as a biomedical research enterprise and a range of public-service initiatives throughout the state. One of the fastest-growing academic health centers in the country,[citation needed] UMMS is located in Worcester, Massachusetts; other UMass sites are located in Amherst, Boston, Dartmouth and Lowell. UMMS is also known as UMass Worcester.

The school is ranked 5th in primary-care education and 49th in research among the United States 128 medical schools in the 2015 U.S. News & World Report annual guide, "America’s Best Graduate Schools”. During the past four decades UMMS researchers have made advances in a broad range of disease families, from HIV and infectious diseases to cancer, genetic disorders, diabetes and immune disease. UMMS faculty discovered the link between the immune system and type-1 diabetes, found the genetic cause underlying the third-most-common form of the muscular dystrophies, established the fundamental difference between HIV and other retroviruses and co-discovered RNA interference (RNAi) (a naturally occurring gene-silencing process which has become a tool in research focused on such areas as diabetes, HIV/AIDS and cancer).